Five dysfunctional telomeres predict onset of senescence in human cells
Five dysfunctional telomeres predict onset of senescence in human cells
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Contents
Replicative senescence is accompanied by a telomere‐specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early‐passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1 proteins, are not associated with end‐to‐end fusi...
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Full title
Five dysfunctional telomeres predict onset of senescence in human cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3246253
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3246253
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2011.227
