Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers thera...
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and rescue of IgG3 is inhibited in the presence of IgG1 due to intracellular competition between IgG1 and IgG3. We reveal that this...
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Full title
Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3247843
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3247843
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms1608
