Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Phospholipase A₂ (PLA₂) enzymes are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here, we show that a distinct pathway exists in brain, where monoacylglycerol Upase (MAGL) hydrolyzes the endocannabinoid 2-arachidonoylglycerol to generate a major arachidonate precursor pool for n...
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Full title
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3249428
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3249428
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1209200
