Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA met...
Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation
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Publisher
Basingstoke: Elsevier Inc
Journal title
Language
English
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Publisher
Basingstoke: Elsevier Inc
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Scope and Contents
Contents
The expression of the renoprotective antiaging gene Klotho is decreased in uremia. Recent studies suggest that Klotho may be a tumor suppressor, and its expression may be repressed by DNA hypermethylation in cancer cells. Here we investigated the effects and possible mechanisms by which Klotho expression is regulated during uremia in uninephrectomi...
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Full title
Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3306006
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3306006
Other Identifiers
ISSN
0085-2538
E-ISSN
1523-1755
DOI
10.1038/ki.2011.445
