Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α‐melanocyte‐stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and α‐MSH level...
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Full title
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137
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ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2011.260