Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
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Author / Creator
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α‐melanocyte‐stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and α‐MSH level...
Alternative Titles
Full title
Loss of autophagy in hypothalamic POMC neurons impairs lipolysis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2011.260
