Log in to save to my catalogue

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

About this item

Full title

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Publisher

Chichester, UK: John Wiley & Sons, Ltd

Journal title

EMBO reports, 2012-03, Vol.13 (3), p.258-265

Language

English

Formats

Publication information

Publisher

Chichester, UK: John Wiley & Sons, Ltd

More information

Scope and Contents

Contents

Autophagy degrades cytoplasmic contents to achieve cellular homeostasis. We show that selective loss of autophagy in hypothalamic proopiomelanocortin (POMC) neurons decreases α‐melanocyte‐stimulating hormone (MSH) levels, promoting adiposity, impairing lipolysis and altering glucose homeostasis. Ageing reduces hypothalamic autophagy and α‐MSH level...

Alternative Titles

Full title

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3323137

Other Identifiers

ISSN

1469-221X

E-ISSN

1469-3178

DOI

10.1038/embor.2011.260

How to access this item