Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysacch...
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Deficiency of glycosaminoglycan (GAG) degradation causes a subclass of lysosomal storage disorders called mucopolysaccharidoses (MPSs), many of which present with severe neuropathology. Critical steps in the degradation of the GAG heparan sulfate remain enigmatic. Here we show that the lysosomal arylsulfatase G (ARSG) is the long-sought glucosamine...
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Full title
Arylsulfatase G inactivation causes loss of heparan sulfate 3-O-sulfatase activity and mucopolysaccharidosis in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387061
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387061
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1202071109
