mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
About this item
Full title
Author / Creator
Yilmaz, Ömer H. , Katajisto, Pekka , Lamming, Dudley W. , Gültekin, Yetis , Bauer-Rowe, Khristian E. , Sengupta, Shomit , Birsoy, Kivanc , Dursun, Abdulmetin , Yilmaz, V. Onur , Selig, Martin , Nielsen, G. Petur , Mino-Kenudson, Mari , Zukerberg, Lawrence R. , Bhan, Atul K. , Deshpande, Vikram and Sabatini, David M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex...
Alternative Titles
Full title
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387287
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3387287
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11163
