ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In response to nutrient stress, cells start an autophagy program that can lead to adaptation or death. The mechanisms underlying the signaling from starvation to the initiation of autophagy are not fully understood. In the current study we show that the absence or inactivation of PARP-1 strongly delays starvation-induced autophagy. We have found th...
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Full title
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3391023
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3391023
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2012.70
