A novel chemometric method for the prediction of human oral bioavailability
A novel chemometric method for the prediction of human oral bioavailability
About this item
Full title
Author / Creator
Xu, Xue , Zhang, Wuxia , Huang, Chao , Li, Yan , Yu, Hua , Wang, Yonghua , Duan, Jinyou and Ling, Yang
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Orally administered drugs must overcome several barriers before reaching their target site. Such barriers depend largely upon specific membrane transport systems and intracellular drug-metabolizing enzymes. For the first time, the P-glycoprotein (P-gp) and cytochrome P450s, the main line of defense by limiting the oral bioavailability (OB) of drugs...
Alternative Titles
Full title
A novel chemometric method for the prediction of human oral bioavailability
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3397506
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3397506
Other Identifiers
ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms13066964
