Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
MLL
fusion genes often encode leukemogenic proteins that depend on interaction with menin, a component of the MLL SET1-like histone methyltransferase complex. MI-2 and MI-3 are the first small molecules that can block menin–MLL fusion protein interaction and their oncogenic effects in cells.
Translocations involving the mixed lineage leukemia...
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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3401603
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3401603
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.773
