K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric di...
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
About this item
Full title
Author / Creator
Khuong-Quang, Dong-Anh , Buczkowicz, Pawel , Rakopoulos, Patricia , Liu, Xiao-Yang , Fontebasso, Adam M. , Bouffet, Eric , Bartels, Ute , Albrecht, Steffen , Schwartzentruber, Jeremy , Letourneau, Louis , Bourgey, Mathieu , Bourque, Guillaume , Montpetit, Alexandre , Bourret, Genevieve , Lepage, Pierre , Fleming, Adam , Lichter, Peter , Kool, Marcel , von Deimling, Andreas , Sturm, Dominik , Korshunov, Andrey , Faury, Damien , Jones, David T. , Majewski, Jacek , Pfister, Stefan M. , Jabado, Nada and Hawkins, Cynthia
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
Subjects
More information
Scope and Contents
Contents
Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3.3) subgroups were compared for
HIST1H3B
,
Alternative Titles
Full title
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Authors, Artists and Contributors
Author / Creator
Buczkowicz, Pawel
Rakopoulos, Patricia
Liu, Xiao-Yang
Fontebasso, Adam M.
Bouffet, Eric
Bartels, Ute
Albrecht, Steffen
Schwartzentruber, Jeremy
Letourneau, Louis
Bourgey, Mathieu
Bourque, Guillaume
Montpetit, Alexandre
Bourret, Genevieve
Lepage, Pierre
Fleming, Adam
Lichter, Peter
Kool, Marcel
von Deimling, Andreas
Sturm, Dominik
Korshunov, Andrey
Faury, Damien
Jones, David T.
Majewski, Jacek
Pfister, Stefan M.
Jabado, Nada
Hawkins, Cynthia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3422615
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3422615
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-012-0998-0
