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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3468323

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

About this item

Full title

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2011-11, Vol.479 (7372), p.232-236

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Role of cell senescence in ageing
Senescent cells accumulate in tissues with age, but it is not known whether they actually cause age-related dysfunction or whether their removal is beneficial. Using a mouse model with a transgene named
INK-ATTAC
, which allows for the inducible elimination of cells carrying the senescence biomarker p16

Alternative Titles

Full title

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3468323

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3468323

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature10600

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