Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Role of cell senescence in ageing
Senescent cells accumulate in tissues with age, but it is not known whether they actually cause age-related dysfunction or whether their removal is beneficial. Using a mouse model with a transgene named
INK-ATTAC
, which allows for the inducible elimination of cells carrying the senescence biomarker p16
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3468323
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3468323
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10600
