Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
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Author / Creator
Chambers, John C , Zhang, Weihua , Li, Xinzhong , Wass, Mark N , Holm, Hilma , Sanna, Serena , Kavousi, Maryam , Coin, Lachlan J , Deng, Guohong , Gieger, Christian , Kühnel, Brigitte , Kumar, Vinod , Lagou, Vasiliki , Luan, Jian'an , Vidal, Pedro Marques , Peden, John F , Rahmioglu, Nilufer , Soininen, Pasi , Speliotes, Elizabeth K , Yuan, Xin , Alizadeh, Behrooz Z , Atwood, Larry D , Borecki, Ingrid B , Brown, Morris J , Charoen, Pimphen , Cucca, Francesco , Das, Debashish , de Geus, Eco J C , Dixon, Anna L , Döring, Angela , Ehret, Georg , Eyjolfsson, Gudmundur I , Farrall, Martin , Forouhi, Nita G , Goessling, Wolfram , Harris, Tamara B , Heath, Simon , Hirschfield, Gideon M , Hofman, Albert , Homuth, Georg , Hyppönen, Elina , Janssen, Harry L A , Johnson, Toby , Kangas, Antti J , Kema, Ido P , Kühn, Jens P , Lai, Sandra , Lathrop, Mark , Lerch, Markus M , Li, Yun , Liang, T Jake , Lin, Jing-Ping , Loos, Ruth J F , Martin, Nicholas G , Moffatt, Miriam F , Musunuru, Kiran , Nakamura, Yusuke , O'Donnell, Christopher J , Pouta, Anneli , Prins, Bram P , Prokopenko, Inga , Puls, Ralf , Schlessinger, David , Schouten, Jeoffrey N L , Seedorf, Udo , Sen-Chowdhry, Srijita , Siminovitch, Katherine A , Spector, Timothy D , Teslovich, Tanya M , Tukiainen, Taru , Van der Klauw, Melanie M , Vasan, Ramachandran S , Wallaschofski, Henri , Wichmann, H-Erich , Willemsen, Gonneke , Würtz, Peter , Xu, Chun , Yerges-Armstrong, Laura M , Abecasis, Goncalo R , Ahmadi, Kourosh R , Caulfield, Mark , Cookson, William O , McCarthy, Mark I , Sternberg, Michael J E , Stolk, Ronald P , Thomas, Howard C , Uda, Manuela , Waeber, Gérard , Waterworth, Dawn M , Watkins, Hugh , Whitfield, John B , Witteman, Jacqueline C M , Wolffenbuttel, Bruce H R , Fox, Caroline S , Vollenweider, Peter , Völzke, Henry , Schadt, Eric E , Järvelin, Marjo-Riitta , Elliott, Paul , Kooner, Jaspal S , Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) , Alcohol Genome-wide Association (AlcGen) Consortium , Genetic Investigation of Anthropometric Traits (GIANT) Consortium , Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study , International Consortium for Blood Pressure (ICBP-GWAS) , Global Lipids Genetics Consortium and Genetics of Liver Disease (GOLD) Consortium
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
John Chambers and colleagues report a genome-wide association study for markers of liver function. They identify 42 loci associated with concentrations of one or more liver enzymes in plasma, and use a range of functional genomic analyses to suggest candidate genes at these loci.
Concentrations of liver enzymes in plasma are widely used as indic...
Alternative Titles
Full title
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Authors, Artists and Contributors
Author / Creator
Zhang, Weihua
Li, Xinzhong
Wass, Mark N
Holm, Hilma
Sanna, Serena
Kavousi, Maryam
Coin, Lachlan J
Deng, Guohong
Gieger, Christian
Kühnel, Brigitte
Kumar, Vinod
Lagou, Vasiliki
Luan, Jian'an
Vidal, Pedro Marques
Peden, John F
Rahmioglu, Nilufer
Soininen, Pasi
Speliotes, Elizabeth K
Yuan, Xin
Alizadeh, Behrooz Z
Atwood, Larry D
Borecki, Ingrid B
Brown, Morris J
Charoen, Pimphen
Cucca, Francesco
Das, Debashish
de Geus, Eco J C
Dixon, Anna L
Döring, Angela
Ehret, Georg
Eyjolfsson, Gudmundur I
Farrall, Martin
Forouhi, Nita G
Goessling, Wolfram
Harris, Tamara B
Heath, Simon
Hirschfield, Gideon M
Hofman, Albert
Homuth, Georg
Hyppönen, Elina
Janssen, Harry L A
Johnson, Toby
Kangas, Antti J
Kema, Ido P
Kühn, Jens P
Lai, Sandra
Lathrop, Mark
Lerch, Markus M
Li, Yun
Liang, T Jake
Lin, Jing-Ping
Loos, Ruth J F
Martin, Nicholas G
Moffatt, Miriam F
Musunuru, Kiran
Nakamura, Yusuke
O'Donnell, Christopher J
Pouta, Anneli
Prins, Bram P
Prokopenko, Inga
Puls, Ralf
Schlessinger, David
Schouten, Jeoffrey N L
Seedorf, Udo
Sen-Chowdhry, Srijita
Siminovitch, Katherine A
Spector, Timothy D
Teslovich, Tanya M
Tukiainen, Taru
Van der Klauw, Melanie M
Vasan, Ramachandran S
Wallaschofski, Henri
Wichmann, H-Erich
Willemsen, Gonneke
Würtz, Peter
Xu, Chun
Yerges-Armstrong, Laura M
Abecasis, Goncalo R
Ahmadi, Kourosh R
Caulfield, Mark
Cookson, William O
McCarthy, Mark I
Sternberg, Michael J E
Stolk, Ronald P
Thomas, Howard C
Uda, Manuela
Waeber, Gérard
Waterworth, Dawn M
Watkins, Hugh
Whitfield, John B
Witteman, Jacqueline C M
Wolffenbuttel, Bruce H R
Fox, Caroline S
Vollenweider, Peter
Völzke, Henry
Schadt, Eric E
Järvelin, Marjo-Riitta
Elliott, Paul
Kooner, Jaspal S
Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)
Alcohol Genome-wide Association (AlcGen) Consortium
Genetic Investigation of Anthropometric Traits (GIANT) Consortium
Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study
International Consortium for Blood Pressure (ICBP-GWAS)
Global Lipids Genetics Consortium
Genetics of Liver Disease (GOLD) Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3482372
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3482372
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.970
