Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
GPR88 is an orphan G protein–coupled receptor expressed in striatal medium spiny neurons (MSNs). The authors show that deletion of
Gpr88
in mice leads to hyperactivity, poor motor coordination and impaired cue-based learning. MSNs lacking GPR88 show increased excitation and reduced inhibition
in vitro
, and enhanced firing rates
in v...
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Full title
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3483418
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3483418
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3239
