Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
About this item
Full title
Author / Creator
Chang, Suhwan , Wang, Rui-Hong , Akagi, Keiko , Kim, Kyung-Ae , Martin, Betty K , Cavallone, Luca , Haines, Diana C , Basik, Mark , Mai, Phuong , Poggi, Elizabeth , Isaacs, Claudine , Looi, Lai M , Mun, Kein S , Greene, Mark H , Byers, Stephen W , Teo, Soo H , Deng, Chu-Xia , Sharan, Shyam K and Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
BRCA1 loss of function is considered to promote tumorigenesis through impairment of the protein's role in DNA damage repair. By studying
BRCA1
mutations that do not affect this function but still confer cancer predisposition, this report identifies a new function of BRCA1, the repression of miR-155 through modulation of HDAC activity. miR-155...
Alternative Titles
Full title
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155
Authors, Artists and Contributors
Author / Creator
Wang, Rui-Hong
Akagi, Keiko
Kim, Kyung-Ae
Martin, Betty K
Cavallone, Luca
Haines, Diana C
Basik, Mark
Mai, Phuong
Poggi, Elizabeth
Isaacs, Claudine
Looi, Lai M
Mun, Kein S
Greene, Mark H
Byers, Stephen W
Teo, Soo H
Deng, Chu-Xia
Sharan, Shyam K
Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3501198
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3501198
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2459
