Silencing of microRNA families by seed-targeting tiny LNAs
Silencing of microRNA families by seed-targeting tiny LNAs
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Sakari Kauppinen and colleagues report a method for silencing miRNA families
in vivo
. They find that seed-targeting 8-mer LNA oligonucleotides, termed tiny LNAs, can lead to long-term miRNA silencing in normal tissues and breast tumors in mice.
The challenge of understanding the widespread biological roles of animal microRNAs (miRNAs) has...
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Full title
Silencing of microRNA families by seed-targeting tiny LNAs
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3541685
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3541685
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.786
