PAR-1 contributes to the innate immune response during viral infection
PAR-1 contributes to the innate immune response during viral infection
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Author / Creator
Antoniak, Silvio , Owens, 3rd, A Phillip , Baunacke, Martin , Williams, Julie C , Lee, Rebecca D , Weithäuser, Alice , Sheridan, Patricia A , Malz, Ronny , Luyendyk, James P , Esserman, Denise A , Trejo, JoAnn , Kirchhofer, Daniel , Blaxall, Burns C , Pawlinski, Rafal , Beck, Melinda A , Rauch, Ursula and Mackman, Nigel
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3-induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1(-/-) mice expressed reduced levels of IFN-β and CX...
Alternative Titles
Full title
PAR-1 contributes to the innate immune response during viral infection
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3582138
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3582138
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI66125
