CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
About this item
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Author / Creator
Hong, Jian , Hu, Kaishun , Yuan, Yunfei , Sang, Yi , Bu, Qiangui , Chen, Guihua , Yang, Longjun , Li, Binkui , Huang, Pinzhu , Chen, Dongtai , Liang, Yi , Zhang, Ruhua , Pan, Jingxuan , Zeng, Yi-Xin and Kang, Tiebang
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic targets for HCC. In this study, we found that checkpoint kinase 1 (CHK1) was frequently overexpressed and correlated with poor clinical outcome in patients with HCC. We fur...
Alternative Titles
Full title
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589177
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589177
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI61380
