Genome-wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vacc...
Genome-wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vaccinology
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Publisher
England: BioMed Central
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Language
English
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England: BioMed Central
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Contents
Herpes simplex virus (HSV) types 1 and 2 (HSV-1 and HSV-2) are the most common infectious agents of humans. No safe and effective HSV vaccines have been licensed. Reverse vaccinology is an emerging and revolutionary vaccine development strategy that starts with the prediction of vaccine targets by informatics analysis of genome sequences. Vaxign (http://www.violinet.org/vaxign) is the first web-based vaccine design program based on reverse vaccinology. In this study, we used Vaxign to analyze 52 herpesvirus genomes, including 3 HSV-1 genomes, one HSV-2 genome, 8 other human herpesvirus genomes, and 40 non-human herpesvirus genomes. The HSV-1 strain 17 genome that contains 77 proteins was used as the seed genome. The...
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Full title
Genome-wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vaccinology
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3599071
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3599071
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ISSN
1471-2105
E-ISSN
1471-2105
DOI
10.1186/1471-2105-14-S4-S2
