Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor...
Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The recently discovered 150-cavity (formed by loop residues 147–152, N2 numbering) adjacent to the enzymatic active site of group 1 influenza A neuraminidase (NA) has introduced a novel target for the design of next-generation NA inhibitors. However, only group 1 NAs, with the exception of the 2009 pandemic H1N1 NA, possess a 150-cavity and no 150-...
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Full title
Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3609017
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3609017
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep01551
