Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
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Author / Creator
Diala, Irmina , Wagner, Nicole , Magdinier, Frédérique , Shkreli, Marina , Sirakov, Maria , Bauwens, Serge , Schluth-Bolard, Caroline , Simonet, Thomas , Renault, Valérie M , Ye, Jing , Djerbi, Abdelnnadir , Pineau, Pascal , Choi, Jinkuk , Artandi, Steven , Dejean, Anne , Plateroti, Michelina and Gilson, Eric
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
The DNA‐binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/β‐catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, β‐catenin binds to TRF2 gene regulatory regions that are functional in a l...
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Full title
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3615653
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3615653
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2013.16
