Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
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Author / Creator
Pera, Marta , Alcolea, Daniel , Sánchez-Valle, Raquel , Guardia-Laguarta, Cristina , Colom-Cadena, Martí , Badiola, Nahuai , Suárez-Calvet, Marc , Lladó, Albert , Barrera-Ocampo, Alvaro A. , Sepulveda-Falla, Diego , Blesa, Rafael , Molinuevo, José L. , Clarimón, Jordi , Ferrer, Isidre , Gelpi, Ellen and Lleó, Alberto
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
Formats
Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
Subjects
More information
Scope and Contents
Contents
Autosomal-dominant Alzheimer disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (
APP
) or Presenilin (
PSEN
) genes. Studies from families with ADAD have been critical to support the amyloid cascade hypothesis of Alzheimer disease (AD), the basis for the current development of amyloid-based disease-mo...
Alternative Titles
Full title
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3623032
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3623032
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-012-1062-9
