EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
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Author / Creator
Xu, Kexin , Wu, Zhenhua Jeremy , Groner, Anna C. , He, Housheng Hansen , Cai, Changmeng , Lis, Rosina T. , Wu, Xiaoqiu , Stack, Edward C. , Loda, Massimo , Liu, Tao , Xu, Han , Cato, Laura , Thornton, James E. , Gregory, Richard I. , Morrissey, Colm , Vessella, Robert L. , Montironi, Rodolfo , Magi-Galluzzi, Cristina , Kantoff, Philip W. , Balk, Steven P. , Liu, X. Shirley and Brown, Myles
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independ...
Alternative Titles
Full title
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
Authors, Artists and Contributors
Author / Creator
Wu, Zhenhua Jeremy
Groner, Anna C.
He, Housheng Hansen
Cai, Changmeng
Lis, Rosina T.
Wu, Xiaoqiu
Stack, Edward C.
Loda, Massimo
Liu, Tao
Xu, Han
Cato, Laura
Thornton, James E.
Gregory, Richard I.
Morrissey, Colm
Vessella, Robert L.
Montironi, Rodolfo
Magi-Galluzzi, Cristina
Kantoff, Philip W.
Balk, Steven P.
Liu, X. Shirley
Brown, Myles
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3625962
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3625962
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1227604
