Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The CXXC domains of TET2 (encoded by the distinct gene
IDAX
) and TET3 are found to have previously unknown roles in the regulation of TET proteins through the activation of caspases and subsequent reduction in TET catalytic activity; this regulation is dependent on DNA binding through the CXXC domain.
IDAX regulates TET2 protein expressio...
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Full title
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3643997
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3643997
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12052
