Structural Basis for Molecular Recognition at Serotonin Receptors
Structural Basis for Molecular Recognition at Serotonin Receptors
About this item
Full title
Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Wang, Chong , Jiang, Yi , Ma, Jinming , Wu, Huixian , Wacker, Daniel , Katritch, Vsevolod , Han, Gye Won , Liu, Wei , Huang, Xi-Ping , Vardy, Eyal , McCorvy, John D. , Gao, Xiang , Zhou, X. Edward , Melcher, Karsten , Zhang, Chenghai , Bai, Fang , Yang, Huaiyu , Yang, Linlin , Jiang, Hualiang , Roth, Bryan L. , Cherezov, Vadim , Stevens, Raymond C. and Xu, H. Eric
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the human 5-HT 1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine. The structures reveal similar binding modes for these ligands, which...
Alternative Titles
Full title
Structural Basis for Molecular Recognition at Serotonin Receptors
Authors, Artists and Contributors
Author / Creator
Wang, Chong
Jiang, Yi
Ma, Jinming
Wu, Huixian
Wacker, Daniel
Katritch, Vsevolod
Han, Gye Won
Liu, Wei
Huang, Xi-Ping
Vardy, Eyal
McCorvy, John D.
Gao, Xiang
Zhou, X. Edward
Melcher, Karsten
Zhang, Chenghai
Bai, Fang
Yang, Huaiyu
Yang, Linlin
Jiang, Hualiang
Roth, Bryan L.
Cherezov, Vadim
Stevens, Raymond C.
Xu, H. Eric
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3644373
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3644373
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1232807
