Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Structure-based design of RARα antagonists leads to compounds that can selectively upregulate chaperone-mediated autophagy (CMA), yielding the first chemically tractable target for regulating CMA in cells.
Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradat...
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Full title
Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3661710
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3661710
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1230