Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment...
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging
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England: Nature Publishing Group
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English
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England: Nature Publishing Group
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We previously reported cognitive dysfunction in klotho mutant mice. In the present study, we further examined novel mechanisms involved in cognitive impairment in these mice. Significantly decreased janus kinase 2 (JAK2) and signal transducer and activator of transcription3 (STAT3) phosphorylation were observed in the hippocampus of klotho mutant m...
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Full title
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3682136
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3682136
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ISSN
0893-133X
E-ISSN
1740-634X
DOI
10.1038/npp.2013.39
