Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
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Author / Creator
Metallo, Christian M. , Gameiro, Paulo A. , Bell, Eric L. , Mattaini, Katherine R. , Yang, Juanjuan , Hiller, Karsten , Jewell, Christopher M. , Johnson, Zachary R. , Irvine, Darrell J. , Guarente, Leonard , Kelleher, Joanne K. , Vander Heiden, Matthew G. , Iliopoulos, Othon and Stephanopoulos, Gregory
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Alternative route to fatty acids
Oxidative metabolism of glucose has long been considered to be the major provider of carbon for lipid synthesis in animal cells. Two papers in this issue of
Nature
demonstrate that reductive carboxylation of glutamine is an alternative. Metallo
et al
. show that various normal and cancerous human cell...
Alternative Titles
Full title
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3710581
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3710581
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10602
