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Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715993

Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

About this item

Full title

Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Publisher

Washington, DC: American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2012-05, Vol.336 (6081), p.597-601

Language

English

Formats

Publication information

Publisher

Washington, DC: American Association for the Advancement of Science

More information

Scope and Contents

Contents

Major features of the transcellular signaling mechanism responsible for endothelium-dependent regulation of vascular smooth muscle tone are unresolved. We identified local calcium (Ca²⁺) signals ("sparklets") in the vascular endothelium of resistance arteries that represent Ca²⁺ influx through single TRPV4 cation channels. Gating of individual TRPV...

Alternative Titles

Full title

Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715993

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715993

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.1216283

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