Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function
Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function
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Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
Major features of the transcellular signaling mechanism responsible for endothelium-dependent regulation of vascular smooth muscle tone are unresolved. We identified local calcium (Ca²⁺) signals ("sparklets") in the vascular endothelium of resistance arteries that represent Ca²⁺ influx through single TRPV4 cation channels. Gating of individual TRPV...
Alternative Titles
Full title
Elementary Ca²⁺ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715993
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3715993
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1216283
