Synergistic and tunable human gene activation by combinations of synthetic transcription factors
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The combination of several TALE-TFs that bind the same gene promoter at different positions induces high and tunable activation, even in heterochromatic genes, and offers the promise of engineering complex synthetic gene expression systems.
Mammalian genes are regulated by the cooperative and synergistic actions of many transcription factors. In...
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Full title
Synergistic and tunable human gene activation by combinations of synthetic transcription factors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3719416
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3719416
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/nmeth.2361
