Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
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Publisher
United States: Elsevier Inc
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Language
English
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United States: Elsevier Inc
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Contents
Cancer-associated fibroblasts (CAFs), the principle component of the tumor-associated stroma, form a highly protumorigenic and immunosuppressive microenvironment that mediates therapeutic resistance. Co-targeting CAFs in addition to cancer cells may therefore augment the antitumor response. Fibroblast activation protein-α (FAP), a type 2 dipeptidyl...
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Full title
Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3734659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3734659
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ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2013.110
