Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
About this item
Full title
Author / Creator
Hunt, Karen A. , Mistry, Vanisha , Bockett, Nicholas A. , Ahmad, Tariq , Ban, Maria , Barker, Jonathan N. , Barrett, Jeffrey C. , Blackburn, Hannah , Brand, Oliver , Burren, Oliver , Capon, Francesca , Compston, Alastair , Gough, Stephen C. L. , Jostins, Luke , Kong, Yong , Lee, James C. , Lek, Monkol , MacArthur, Daniel G. , Mansfield, John C. , Mathew, Christopher G. , Mein, Charles A. , Mirza, Muddassar , Nutland, Sarah , Onengut-Gumuscu, Suna , Papouli, Efterpi , Parkes, Miles , Rich, Stephen S. , Sawcer, Steven , Satsangi, Jack , Simmonds, Matthew J. , Trembath, Richard C. , Walker, Neil M. , Wozniak, Eva , Todd, John A. , Simpson, Michael A. , Plagnol, Vincent and van Heel, David A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A search for variants in coding exons of 25 genome-wide association study risk genes in a large cohort of autoimmune patients finds that rare coding-region variants at known loci have a negligible role in common autoimmune disease susceptibility, arguing against the previously proposed rare-variant synthetic genome-wide association hypothesis.
I...
Alternative Titles
Full title
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability
Authors, Artists and Contributors
Author / Creator
Mistry, Vanisha
Bockett, Nicholas A.
Ahmad, Tariq
Ban, Maria
Barker, Jonathan N.
Barrett, Jeffrey C.
Blackburn, Hannah
Brand, Oliver
Burren, Oliver
Capon, Francesca
Compston, Alastair
Gough, Stephen C. L.
Jostins, Luke
Kong, Yong
Lee, James C.
Lek, Monkol
MacArthur, Daniel G.
Mansfield, John C.
Mathew, Christopher G.
Mein, Charles A.
Mirza, Muddassar
Nutland, Sarah
Onengut-Gumuscu, Suna
Papouli, Efterpi
Parkes, Miles
Rich, Stephen S.
Sawcer, Steven
Satsangi, Jack
Simmonds, Matthew J.
Trembath, Richard C.
Walker, Neil M.
Wozniak, Eva
Todd, John A.
Simpson, Michael A.
Plagnol, Vincent
van Heel, David A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3736321
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3736321
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12170
