A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Zhao and colleagues find that neuropathic pain is accompanied by an increase in the expression of an antisense long noncoding RNA (lncRNA) that downregulates Kcna2 currents and increases excitability in rat dorsal root ganglion neurons. Preventing the expression of the so-called Kcna2 antisense RNA mitigates neuropathic pain symptoms.
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Full title
A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3742386
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3742386
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3438
