Structural mechanism of cytosolic DNA sensing by cGAS
Structural mechanism of cytosolic DNA sensing by cGAS
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune host defence by the production of type I interferon and inflammatory cytokines. Recognition of cytosolic DNA by the recently discovered cyclic-GMP-AMP (cGAMP) synthase (cGAS) induces the produ...
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Full title
Structural mechanism of cytosolic DNA sensing by cGAS
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3768140
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3768140
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12305
