Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Mutations in superoxide dismutase-1 (SOD1) cause a form of the fatal paralytic disorder amyotrophic lateral sclerosis (ALS), presumably by a combination of cell-autonomous and non–cell-autonomous processes. Here, we show that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration. Conversel...
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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3799799
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3799799
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn1876
