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ArticlesPeer ReviewedFull Text
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
Author / Creator:Re, Diane B. ; Le Verche, Virginia ; Yu, Changhao ; Amoroso, Mackenzie W. ; Politi, Kristin A. ; Phani, Sudarshan ; Ikiz, Burcin ; Hoffmann, Lucas ; Koolen, Martijn ; Nagata, Tetsuya ; Papadimitriou, Dimitra ; Nagy, Peter ; Mitsumoto, Hiroshi ; Kariya, Shingo ; Wichterle, Hynek ; Henderson, Christopher E. ; Przedborski, Serge
Publisher:United States: Elsevier Inc
Journal title:Neuron (Cambridge, Mass.), 2014-03, Vol.81 (5), p.1001-1008
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ArticlesPeer ReviewedFull Text
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity
Author / Creator:Mazzoni, Esteban O ; Mahony, Shaun ; Closser, Michael ; Morrison, Carolyn A ; Nedelec, Stephane ; Williams, Damian J ; An, Disi ; Gifford, David K ; Wichterle, Hynek
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2013-09, Vol.16 (9), p.1219-1227
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ArticlesPeer ReviewedFull Text
Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
Author / Creator:Patel, Tulsi ; Hammelman, Jennifer ; Aziz, Siaresh ; Jang, Sumin ; Closser, Michael ; Michaels, Theodore L. ; Blum, Jacob A. ; Gifford, David K. ; Wichterle, Hynek
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-09, Vol.13 (1), p.5427-5427, Article 5427
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Newsletter articlesFull Text
Wichterle Hynek, Henderson Christopher E and Thams Sebastian Apply for Patent on Methods for Identifying Candidates for the Treatment of Neurodegenerative Diseases
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Medical Patent News, 2015
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ArticlesPeer ReviewedFull Text
A functionally characterized test set of human induced pluripotent stem cells
Author / Creator:Boulting, Gabriella L ; Kiskinis, Evangelos ; Croft, Gist F ; Amoroso, Mackenzie W ; Oakley, Derek H ; Wainger, Brian J ; Williams, Damian J ; Kahler, David J ; Yamaki, Mariko ; Davidow, Lance ; Rodolfa, Christopher T ; Dimos, John T ; Mikkilineni, Shravani ; MacDermott, Amy B ; Woolf, Clifford J ; Henderson, Christopher E ; Wichterle, Hynek ; Eggan, Kevin
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2011-03, Vol.29 (3), p.279-286
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ArticlesPeer ReviewedFull Text
What can pluripotent stem cells teach us about neurodegenerative diseases?
Author / Creator:Wichterle, Hynek ; Przedborski, Serge
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2010-07, Vol.13 (7), p.800-804
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ArticlesPeer ReviewedFull Text
Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals
Author / Creator:Mazzoni, Esteban O ; Mahony, Shaun ; Peljto, Mirza ; Patel, Tulsi ; Thornton, Seraphim R ; McCuine, Scott ; Reeder, Christopher ; Boyer, Laurie A ; Young, Richard A ; Gifford, David K ; Wichterle, Hynek
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2013-09, Vol.16 (9), p.1191-1198
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ArticlesPeer ReviewedFull Text
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons
Author / Creator:An, Disi ; Fujiki, Ryosuke ; Iannitelli, Dylan E ; Smerdon, John W ; Maity, Shuvadeep ; Rose, Matthew F ; Gelber, Alon ; Wanaselja, Elizabeth K ; Yagudayeva, Ilona ; Lee, Joun Y ; Vogel, Christine ; Wichterle, Hynek ; Engle, Elizabeth C ; Mazzoni, Esteban Orlando
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2019-06, Vol.8
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ArticlesPeer ReviewedFull Text
Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)
Author / Creator:Larrea, Delfina ; Tamucci, Kirstin A. ; Kabra, Khushbu ; Velasco, Kevin R. ; Yun, Taekyung D. ; Pera, Marta ; Montesinos, Jorge ; Agrawal, Rishi R. ; Paradas, Carmen ; Smerdon, John W. ; Lowry, Emily R. ; Stepanova, Anna ; Yoval-Sanchez, Belem ; Galkin, Alexander ; Wichterle, Hynek ; Area-Gomez, Estela
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-01, Vol.16 (1), p.379-20, Article 379
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ArticlesPeer ReviewedFull Text
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis
Author / Creator:Mahony, Shaun ; Mazzoni, Esteban O ; McCuine, Scott ; Young, Richard A ; Wichterle, Hynek ; Gifford, David K
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology (Online Edition), 2011-01, Vol.12 (1), p.R2, Article R2
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ArticlesPeer ReviewedFull Text
New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain
Author / Creator:Sawamoto, Kazunobu ; Wichterle, Hynek ; Gonzalez-Perez, Oscar ; Cholfin, Jeremy A. ; Yamada, Masayuki ; Spassky, Nathalie ; Murcia, Noel S. ; Garcia-Verdugo, Jose Manuel ; Marin, Oscar ; John L. R. Rubenstein ; Tessier-Lavigne, Marc ; Okano, Hideyuki ; Alvarez-Buylla, Arturo
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2006-02, Vol.311 (5761), p.629-632
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ArticlesPeer ReviewedFull Text
Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy
Author / Creator:Johnson-Kerner, Bethany L ; Garcia Diaz, Alejandro ; Ekins, Sean ; Wichterle, Hynek
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-10, Vol.10 (10), p.e0140157-e0140157
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ArticlesPeer ReviewedFull Text
Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures
Author / Creator:Lamas, Nuno Jorge ; Johnson-Kerner, Bethany ; Roybon, Laurent ; Kim, Yoon A ; Garcia-Diaz, Alejandro ; Wichterle, Hynek ; Henderson, Christopher E
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-10, Vol.9 (10), p.e110324-e110324
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ArticlesPeer ReviewedFull Text
An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding
Author / Creator:Mahony, Shaun ; Edwards, Matthew D ; Mazzoni, Esteban O ; Sherwood, Richard I ; Kakumanu, Akshay ; Morrison, Carolyn A ; Wichterle, Hynek ; Gifford, David K
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2014-03, Vol.10 (3), p.e1003501-e1003501
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ArticlesPeer ReviewedFull Text
Maturation of spinal motor neurons derived from human embryonic stem cells
Author / Creator:Takazawa, Tomonori ; Croft, Gist F ; Amoroso, Mackenzie W ; Studer, Lorenz ; Wichterle, Hynek ; Macdermott, Amy B
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-07, Vol.7 (7), p.e40154-e40154
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ArticlesPeer ReviewedFull Text
High resolution mapping of enhancer-promoter interactions
Author / Creator:Reeder, Christopher ; Closser, Michael ; Poh, Huay Mei ; Sandhu, Kuljeet ; Wichterle, Hynek ; Gifford, David
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-05, Vol.10 (5), p.e0122420-e0122420
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ArticlesPeer ReviewedFull Text
Identification of a Small Molecule Inhibitor of the Hedgehog Signaling Pathway: Effects on Basal Cell Carcinoma-like Lesions
Author / Creator:Williams, Juliet A. ; Guicherit, Oivin M. ; Zaharian, Beatrice I. ; Xu, Yin ; Chai, Ling ; Wichterle, Hynek ; Kon, Charlene ; Gatchalian, Christine ; Porter, Jeffery A. ; Rubin, Lee L. ; Wang, Frank Y.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (8), p.4616-4621
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ArticlesPeer ReviewedFull Text
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
Author / Creator:Frank-Kamenetsky, Maria ; Zhang, Xiaoyan M ; Bottega, Steve ; Guicherit, Oivin ; Wichterle, Hynek ; Dudek, Henryk ; Bumcrot, David ; Wang, Frank Y ; Jones, Simon ; Shulok, Janine ; Rubin, Lee L ; Porter, Jeffery A
Publisher:England: BioMed Central Ltd
Journal title:Journal of biology (London, England), 2002-11, Vol.1 (2), p.10-10, Article 10
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ArticlesPeer ReviewedFull Text
Permissive Corridor and Diffusible Gradients Direct Medial Ganglionic Eminence Cell Migration to the Neocortex
Author / Creator:Wichterle, Hynek ; Alvarez-Dolado, Manuel ; Erskine, Lynda ; Alvarez-Buylla, Arturo
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2003-01, Vol.100 (2), p.727-732
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ArticlesPeer ReviewedFull Text
Olig2⁺ Neuroepithelial Motoneuron Progenitors Are Not Multipotent Stem cells in vivo
Author / Creator:Mukouyama, Yoh-suke ; Deneen, Benjamin ; Lukaszewicz, Agnès ; Novitch, Bennett G. ; Wichterle, Hynek ; Jessell, Thomas M. ; Anderson, David J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (5), p.1551-1556
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Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

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Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity

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Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro

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Wichterle Hynek, Henderson Christopher E and Thams Sebastian Apply for Patent on Methods for Identifying Candidates for the Treatment of Neurodegenerative Diseases

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A functionally characterized test set of human induced pluripotent stem cells

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What can pluripotent stem cells teach us about neurodegenerative diseases?

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Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

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Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons

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Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)

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Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis

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New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

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Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy

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Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures

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An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding

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Maturation of spinal motor neurons derived from human embryonic stem cells

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High resolution mapping of enhancer-promoter interactions

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Identification of a Small Molecule Inhibitor of the Hedgehog Signaling Pathway: Effects on Basal Cell Carcinoma-like Lesions

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

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Permissive Corridor and Diffusible Gradients Direct Medial Ganglionic Eminence Cell Migration to the Neocortex

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Olig2⁺ Neuroepithelial Motoneuron Progenitors Are Not Multipotent Stem cells in vivo

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