Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Here, by developing a high-affinity camelid antibody fragment that stabilizes the active state of the β
2
-adrenoceptor, the X-ray crystal structures of the receptor in complex with three agonists, including adrenaline, were determined.
Structure of the activated β
2
-adrenoceptor
This study reports three structures of fully activ...
Alternative Titles
Full title
Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3822040
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3822040
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12572
