C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant S...
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Accumulating evidence from mice expressing ALS-causing mutations in superoxide dismutase (SOD1) has implicated pathological immune responses in motor neuron degeneration. This includes microglial activation, lymphocyte infiltration, and the induction of C1q, the initiating component of the classic complement system that is the protein-based arm of...
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Full title
C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3831990
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3831990
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1318309110
