Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The MuTect algorithm for calling somatic point mutations enables subclonal analysis of the whole-genome or whole-exome sequencing data being generated in large-scale cancer genomics projects.
Detection of somatic point substitutions is a key step in characterizing the cancer genome. However, existing methods typically miss low-allelic-fraction m...
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Full title
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3833702
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3833702
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.2514
