Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic...
Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid
About this item
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Author / Creator
Justinova, Zuzana , Mascia, Paola , Wu, Hui-Qiu , Secci, Maria E , Redhi, Godfrey H , Panlilio, Leigh V , Scherma, Maria , Barnes, Chanel , Parashos, Alexandra , Zara, Tamara , Fratta, Walter , Solinas, Marcello , Pistis, Marco , Bergman, Jack , Kangas, Brian D , Ferré, Sergi , Tanda, Gianluigi , Schwarcz, Robert and Goldberg, Steven R
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
α7-nicotinic acetylcholine receptors (α7nAChRs) modulate the effects of the main psychoactive ingredient of marijuana, Δ
9
-tetrahydrocannabinol (THC), in the brain. Here the authors show that pharmacologically enhancing kynurenic acid, an endogenous modulator of α7nAChRs, attenuated the rewarding properties of THC and prevented drug relapse...
Alternative Titles
Full title
Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3835353
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3835353
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3540
