Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertensi...
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
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Author / Creator
Zhu, Qing , Hu, Junping , Han, Wei-Qing , Zhang, Fan , Li, Pin-Lan , Wang, Zhengchao and Li, Ningjun
Publisher
United States: Oxford University Press
Journal title
Language
English
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Publisher
United States: Oxford University Press
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Contents
In response to high salt intake, transcription factor hypoxia-inducible factor (HIF) 1α activates many antihypertensive genes, such as heme oxygenase 1 (HO-1) 1 and cyclooxygenase 2 (COX-2) in the renal medulla, which is an important molecular adaptation to promote extra sodium excretion. We recently showed that high salt inhibited the expression o...
Alternative Titles
Full title
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3848632
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3848632
Other Identifiers
ISSN
0895-7061
E-ISSN
1941-7225
DOI
10.1093/ajh/hpt207
