Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertensi...
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
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Author / Creator
Zhu, Qing , Hu, Junping , Han, Wei-Qing , Zhang, Fan , Li, Pin-Lan , Wang, Zhengchao and Li, Ningjun
Publisher
United States: Oxford University Press
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Language
English
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Publisher
United States: Oxford University Press
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Contents
In response to high salt intake, transcription factor hypoxia-inducible factor (HIF) 1α activates many antihypertensive genes, such as heme oxygenase 1 (HO-1) 1 and cyclooxygenase 2 (COX-2) in the renal medulla, which is an important molecular adaptation to promote extra sodium excretion. We recently showed that high salt inhibited the expression o...
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Full title
Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3848632
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3848632
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ISSN
0895-7061
E-ISSN
1941-7225
DOI
10.1093/ajh/hpt207