A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
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Author / Creator
Ho, Cheuk Hei , Magtanong, Leslie , Barker, Sarah L , Gresham, David , Nishimura, Shinichi , Natarajan, Paramasivam , Koh, Judice L Y , Porter, Justin , Gray, Christopher A , Andersen, Raymond J , Giaever, Guri , Nislow, Corey , Andrews, Brenda , Botstein, David , Graham, Todd R , Yoshida, Minoru and Boone, Charles
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Knowing a drug's mode of action is invaluable for informing drug discovery efforts. Ho
et al
. construct an optimized yeast genomic library that enables rapid mutant cloning by complementation to guide mode-of-action studies.
We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance,...
Alternative Titles
Full title
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3856559
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3856559
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1534
