Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
About this item
Full title
Author / Creator
Gallo, Elena M , Loch, David C , Habashi, Jennifer P , Calderon, Juan F , Chen, Yichun , Bedja, Djahida , van Erp, Christel , Gerber, Elizabeth E , Parker, Sarah J , Sauls, Kimberly , Judge, Daniel P , Cooke, Sara K , Lindsay, Mark E , Rouf, Rosanne , Myers, Loretha , ap Rhys, Colette M , Kent, Kathleen C , Norris, Russell A , Huso, David L and Dietz, Harry C
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Loeys-Dietz syndrome (LDS) is a connective tissue disorder that is characterized by a high risk for aneurysm and dissection throughout the arterial tree and phenotypically resembles Marfan syndrome. LDS is caused by heterozygous missense mutations in either TGF-β receptor gene (TGFBR1 or TGFBR2), which are predicted to result in diminished TGF-β si...
Alternative Titles
Full title
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
Authors, Artists and Contributors
Author / Creator
Loch, David C
Habashi, Jennifer P
Calderon, Juan F
Chen, Yichun
Bedja, Djahida
van Erp, Christel
Gerber, Elizabeth E
Parker, Sarah J
Sauls, Kimberly
Judge, Daniel P
Cooke, Sara K
Lindsay, Mark E
Rouf, Rosanne
Myers, Loretha
ap Rhys, Colette M
Kent, Kathleen C
Norris, Russell A
Huso, David L
Dietz, Harry C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3871227
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3871227
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI69666
