Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
About this item
Full title
Author / Creator
Killick, R , Ribe, E M , Al-Shawi, R , Malik, B , Hooper, C , Fernandes, C , Dobson, R , Nolan, P M , Lourdusamy, A , Furney, S , Lin, K , Breen, G , Wroe, R , To, A W M , Leroy, K , Causevic, M , Usardi, A , Robinson, M , Noble, W , Williamson, R , Lunnon, K , Kellie, S , Reynolds, C H , Bazenet, C , Hodges, A , Brion, J-P , Stephenson, J , Paul Simons, J and Lovestone, Simon
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Although the mechanism of Aβ action in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of
Dkk1
blocks Aβ neurotoxicity. We asked if clusterin, known to be regulated by wnt, is part of an Aβ/Dkk1 neu...
Alternative Titles
Full title
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
Authors, Artists and Contributors
Author / Creator
Ribe, E M
Al-Shawi, R
Malik, B
Hooper, C
Fernandes, C
Dobson, R
Nolan, P M
Lourdusamy, A
Furney, S
Lin, K
Breen, G
Wroe, R
To, A W M
Leroy, K
Causevic, M
Usardi, A
Robinson, M
Noble, W
Williamson, R
Lunnon, K
Kellie, S
Reynolds, C H
Bazenet, C
Hodges, A
Brion, J-P
Stephenson, J
Paul Simons, J
Lovestone, Simon
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3873038
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3873038
Other Identifiers
ISSN
1359-4184,1476-5578
E-ISSN
1476-5578
DOI
10.1038/mp.2012.163
