Inactivating CUX1 mutations promote tumorigenesis
Inactivating CUX1 mutations promote tumorigenesis
About this item
Full title
Author / Creator
Wong, Chi C , Martincorena, Inigo , Rust, Alistair G , Rashid, Mamunur , Alifrangis, Constantine , Alexandrov, Ludmil B , Tiffen, Jessamy C , Kober, Christina , Green, Anthony R , Massie, Charles E , Nangalia, Jyoti , Lempidaki, Stella , Döhner, Hartmut , Döhner, Konstanze , Bray, Sarah J , McDermott, Ultan , Papaemmanuil, Elli , Campbell, Peter J , Adams, David J and Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
David Adams and colleagues identify inactivating mutations in
CUX1
in diverse human cancers. They validate
CUX1
as a tumor suppressor using mouse and
Drosophila
cancer models, and show that
CUX1
deficiency activates phosphoinositide 3-kinase signaling through transcriptional downregulation of a PI3K inhibitor.
A major cha...
Alternative Titles
Full title
Inactivating CUX1 mutations promote tumorigenesis
Authors, Artists and Contributors
Author / Creator
Martincorena, Inigo
Rust, Alistair G
Rashid, Mamunur
Alifrangis, Constantine
Alexandrov, Ludmil B
Tiffen, Jessamy C
Kober, Christina
Green, Anthony R
Massie, Charles E
Nangalia, Jyoti
Lempidaki, Stella
Döhner, Hartmut
Döhner, Konstanze
Bray, Sarah J
McDermott, Ultan
Papaemmanuil, Elli
Campbell, Peter J
Adams, David J
Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3874239
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3874239
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2846
