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ArticlesPeer ReviewedFull Text
Precision oncology for acute myeloid leukemia using a knowledge bank approach
Author / Creator:Gerstung, Moritz ; Papaemmanuil, Elli ; Martincorena, Inigo ; Bullinger, Lars ; Gaidzik, Verena I ; Paschka, Peter ; Heuser, Michael ; Thol, Felicitas ; Bolli, Niccolo ; Ganly, Peter ; Ganser, Arnold ; McDermott, Ultan ; Döhner, Konstanze ; Schlenk, Richard F ; Döhner, Hartmut ; Campbell, Peter J
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2017-03, Vol.49 (3), p.332-340
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Effect of Mutation Order on Myeloproliferative Neoplasms
Author / Creator:Ortmann, Christina A ; Kent, David G ; Nangalia, Jyoti ; Silber, Yvonne ; Wedge, David C ; Grinfeld, Jacob ; Baxter, E. Joanna ; Massie, Charles E ; Papaemmanuil, Elli ; Menon, Suraj ; Godfrey, Anna L ; Dimitropoulou, Danai ; Guglielmelli, Paola ; Bellosillo, Beatriz ; Besses, Carles ; Döhner, Konstanze ; Harrison, Claire N ; Vassiliou, George S ; Vannucchi, Alessandro ; Campbell, Peter J ; Green, Anthony R
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2015-02, Vol.372 (7), p.601-612
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ArticlesPeer ReviewedFull Text
getITD for FLT3-ITD-based MRD monitoring in AML
Author / Creator:Blätte, Tamara J. ; Schmalbrock, Laura K. ; Skambraks, Sabrina ; Lux, Susanne ; Cocciardi, Sibylle ; Dolnik, Anna ; Döhner, Hartmut ; Döhner, Konstanze ; Bullinger, Lars
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-10, Vol.33 (10), p.2535-2539
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Genomic Classification and Prognosis in Acute Myeloid Leukemia
Author / Creator:Papaemmanuil, Elli ; Gerstung, Moritz ; Bullinger, Lars ; Gaidzik, Verena I ; Paschka, Peter ; Roberts, Nicola D ; Potter, Nicola E ; Heuser, Michael ; Thol, Felicitas ; Bolli, Niccolo ; Gundem, Gunes ; Van Loo, Peter ; Martincorena, Inigo ; Ganly, Peter ; Mudie, Laura ; McLaren, Stuart ; O’Meara, Sarah ; Raine, Keiran ; Jones, David R ; Teague, Jon W ; Butler, Adam P ; Greaves, Mel F ; Ganser, Arnold ; Döhner, Konstanze ; Schlenk, Richard F ; Döhner, Hartmut ; Campbell, Peter J
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2016-06, Vol.374 (23), p.2209-2221
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Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial
Author / Creator:Larson, Richard A. ; Mandrekar, Sumithra J. ; Huebner, Lucas J. ; Sanford, Ben L. ; Laumann, Kristina ; Geyer, Susan ; Bloomfield, Clara D. ; Thiede, Christian ; Prior, Thomas W. ; Döhner, Konstanze ; Marcucci, Guido ; Voso, Maria Teresa ; Klisovic, Rebecca B. ; Galinsky, Ilene ; Wei, Andrew H. ; Sierra, Jorge ; Sanz, Miguel A. ; Brandwein, Joseph M. ; de Witte, Theo ; Niederwieser, Dietger ; Appelbaum, Frederick R. ; Medeiros, Bruno C. ; Tallman, Martin S. ; Krauter, Jürgen ; Schlenk, Richard F. ; Ganser, Arnold ; Serve, Hubert ; Ehninger, Gerhard ; Amadori, Sergio ; Gathmann, Insa ; Döhner, Hartmut ; Stone, Richard M.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-09, Vol.35 (9), p.2539-2551
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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation
Author / Creator:Stone, Richard M ; Mandrekar, Sumithra J ; Sanford, Ben L ; Laumann, Kristina ; Geyer, Susan ; Bloomfield, Clara D ; Thiede, Christian ; Prior, Thomas W ; Döhner, Konstanze ; Marcucci, Guido ; Lo-Coco, Francesco ; Klisovic, Rebecca B ; Wei, Andrew ; Sierra, Jorge ; Sanz, Miguel A ; Brandwein, Joseph M ; de Witte, Theo ; Niederwieser, Dietger ; Appelbaum, Frederick R ; Medeiros, Bruno C ; Tallman, Martin S ; Krauter, Jürgen ; Schlenk, Richard F ; Ganser, Arnold ; Serve, Hubert ; Ehninger, Gerhard ; Amadori, Sergio ; Larson, Richard A ; Döhner, Hartmut
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-08, Vol.377 (5), p.454-464
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ArticlesPeer ReviewedFull Text
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
Author / Creator:Schlenk, Richard F ; Döhner, Konstanze ; Döhner, Hartmut ; Krauter, Jürgen ; Fröhling, Stefan ; Corbacioglu, Andrea ; Bullinger, Lars ; Habdank, Marianne ; Späth, Daniela ; Morgan, Michael ; Benner, Axel ; Schlegelberger, Brigitte ; Heil, Gerhard ; Ganser, Arnold
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2008-05, Vol.358 (18), p.1909-1918
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ArticlesPeer ReviewedFull Text
Germline variants drive myelodysplastic syndrome in young adults
Author / Creator:Feurstein, Simone ; Churpek, Jane E. ; Walsh, Tom ; Keel, Sioban ; Hakkarainen, Marja ; Schroeder, Thomas ; Germing, Ulrich ; Geyh, Stefanie ; Heuser, Michael ; Thol, Felicitas ; Pohlkamp, Christian ; Haferlach, Torsten ; Gao, Juehua ; Owen, Carolyn ; Goehring, Gudrun ; Schlegelberger, Brigitte ; Verma, Divij ; Krause, Daniela S. ; Gao, Guimin ; Cronin, Tara ; Gulsuner, Suleyman ; Lee, Ming ; Pritchard, Colin C. ; Subramanian, Hari Prasanna ; del Gaudio, Daniela ; Li, Zejuan ; Das, Soma ; Kilpivaara, Outi ; Wartiovaara-Kautto, Ulla ; Wang, Eunice S. ; Griffiths, Elizabeth A. ; Döhner, Konstanze ; Döhner, Hartmut ; King, Mary-Claire ; Godley, Lucy A.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-08, Vol.35 (8), p.2439-2444
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ArticlesPeer ReviewedFull Text
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Author / Creator:Zhai, Yanan ; Singh, Prashant ; Dolnik, Anna ; Brazda, Peter ; Atlasy, Nader ; del Gaudio, Nunzio ; Döhner, Konstanze ; Döhner, Hartmut ; Minucci, Saverio ; Martens, Joost ; Altucci, Lucia ; Megchelenbrink, Wout ; Bullinger, Lars ; Stunnenberg, Hendrik G
Publisher:London: BioMed Central Ltd
Journal title:Molecular cancer, 2022-08, Vol.21 (1), p.1-166, Article 166
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ArticlesPeer ReviewedFull Text
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Author / Creator:Li, Sheng ; Garrett-Bakelman, Francine E ; Chung, Stephen S ; Sanders, Mathijs A ; Hricik, Todd ; Rapaport, Franck ; Patel, Jay ; Dillon, Richard ; Vijay, Priyanka ; Brown, Anna L ; Perl, Alexander E ; Cannon, Joy ; Bullinger, Lars ; Luger, Selina ; Becker, Michael ; Lewis, Ian D ; To, Luen Bik ; Delwel, Ruud ; Löwenberg, Bob ; Döhner, Hartmut ; Döhner, Konstanze ; Guzman, Monica L ; Hassane, Duane C ; Roboz, Gail J ; Grimwade, David ; Valk, Peter J M ; D'Andrea, Richard J ; Carroll, Martin ; Park, Christopher Y ; Neuberg, Donna ; Levine, Ross ; Melnick, Ari M ; Mason, Christopher E
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-07, Vol.22 (7), p.792-799
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ArticlesPeer ReviewedFull Text
Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo
Author / Creator:Rummelt, Christoph ; Gorantla, Sivahari P. ; Meggendorfer, Manja ; Charlet, Anne ; Endres, Cornelia ; Döhner, Konstanze ; Heidel, Florian H. ; Fischer, Thomas ; Haferlach, Torsten ; Duyster, Justus ; von Bubnoff, Nikolas
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-07, Vol.35 (7), p.2017-2029
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ArticlesPeer ReviewedFull Text
Inactivating CUX1 mutations promote tumorigenesis
Author / Creator:Wong, Chi C ; Martincorena, Inigo ; Rust, Alistair G ; Rashid, Mamunur ; Alifrangis, Constantine ; Alexandrov, Ludmil B ; Tiffen, Jessamy C ; Kober, Christina ; Green, Anthony R ; Massie, Charles E ; Nangalia, Jyoti ; Lempidaki, Stella ; Döhner, Hartmut ; Döhner, Konstanze ; Bray, Sarah J ; McDermott, Ultan ; Papaemmanuil, Elli ; Campbell, Peter J ; Adams, David J
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2014-01, Vol.46 (1), p.33-38
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ArticlesPeer ReviewedFull Text
Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation
Author / Creator:Cocciardi, Sibylle ; Dolnik, Anna ; Kapp-Schwoerer, Silke ; Rücker, Frank G. ; Lux, Susanne ; Blätte, Tamara J. ; Skambraks, Sabrina ; Krönke, Jan ; Heidel, Florian H. ; Schnöder, Tina M. ; Corbacioglu, Andrea ; Gaidzik, Verena I. ; Paschka, Peter ; Teleanu, Veronica ; Göhring, Gudrun ; Thol, Felicitas ; Heuser, Michael ; Ganser, Arnold ; Weber, Daniela ; Sträng, Eric ; Kestler, Hans A. ; Döhner, Hartmut ; Bullinger, Lars ; Döhner, Konstanze
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-05, Vol.10 (1), p.2031-2031, Article 2031
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The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression
Author / Creator:Gentle, Ian Edward ; Moelter, Isabel ; Badr, Mohamed Tarek ; Döhner, Konstanze ; Lübbert, Michael ; Häcker, Georg
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2021-07, Vol.12 (7), p.675-675, Article 675
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ArticlesPeer ReviewedFull Text
Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia
Author / Creator:Bullinger, Lars ; Döhner, Konstanze ; Döhner, Hartmut ; Bair, Eric ; Fröhling, Stefan ; Schlenk, Richard F ; Tibshirani, Robert ; Pollack, Jonathan R
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2004-04, Vol.350 (16), p.1605-1616
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ArticlesPeer ReviewedFull Text
Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results
Author / Creator:Rücker, Frank G. ; Du, Ling ; Luck, Tamara J. ; Benner, Axel ; Krzykalla, Julia ; Gathmann, Insa ; Voso, Maria Teresa ; Amadori, Sergio ; Prior, Thomas W. ; Brandwein, Joseph M. ; Appelbaum, Frederick R. ; Medeiros, Bruno C. ; Tallman, Martin S. ; Savoie, Lynn ; Sierra, Jorge ; Pallaud, Celine ; Sanz, Miguel A. ; Jansen, Joop H. ; Niederwieser, Dietger ; Fischer, Thomas ; Ehninger, Gerhard ; Heuser, Michael ; Ganser, Arnold ; Bullinger, Lars ; Larson, Richard A. ; Bloomfield, Clara D. ; Stone, Richard M. ; Döhner, Hartmut ; Thiede, Christian ; Döhner, Konstanze
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2022-01, Vol.36 (1), p.90-99
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ArticlesPeer ReviewedFull Text
TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition
Author / Creator:Bamezai, Shiva ; Demir, Deniz ; Pulikkottil, Alex Jose ; Ciccarone, Fabio ; Fischbein, Elena ; Sinha, Amit ; Borga, Chiara ; te Kronnie, Geertruy ; Meyer, Lüder-Hinrich ; Mohr, Fabian ; Götze, Maria ; Caiafa, Paola ; Debatin, Klaus-Michael ; Döhner, Konstanze ; Döhner, Hartmut ; González-Menéndez, Irene ; Quintanilla-Fend, Leticia ; Herold, Tobias ; Jeremias, Irmela ; Feuring-Buske, Michaela ; Buske, Christian ; Rawat, Vijay P. S.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-02, Vol.35 (2), p.389-403
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Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the Ger...
Author / Creator:Stegelmann, Frank ; Wille, Kai ; Busen, Hannah ; Fuchs, Christiane ; Schauer, Stefanie ; Sadjadian, Parvis ; Becker, Tatjana ; Kolatzki, Vera ; Döhner, Hartmut ; Stadler, Rudolf ; Döhner, Konstanze ; Griesshammer, Martin
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-02, Vol.35 (2), p.628-631
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Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia
Author / Creator:Döhner, Konstanze ; Döhner, Hartmut ; Stilgenbauer, Stephan ; Benner, Axel ; Leupolt, Elke ; Kröber, Alexander ; Bullinger, Lars ; Bentz, Martin ; Lichter, Peter
Publisher:Boston, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2000-12, Vol.343 (26), p.1910-1916
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ArticlesPeer ReviewedFull Text
Publisher Correction: Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN)...
Author / Creator:Stegelmann, Frank ; Wille, Kai ; Busen, Hannah ; Fuchs, Christiane ; Schauer, Stefanie ; Sadjadian, Parvis ; Becker, Tatjana ; Kolatzki, Vera ; Döhner, Hartmut ; Stadler, Rudolf ; Döhner, Konstanze ; Griesshammer, Martin
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-12, Vol.35 (12), p.3635-3635
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Precision oncology for acute myeloid leukemia using a knowledge bank approach

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Effect of Mutation Order on Myeloproliferative Neoplasms

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getITD for FLT3-ITD-based MRD monitoring in AML

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Genomic Classification and Prognosis in Acute Myeloid Leukemia

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Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial

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Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

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Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia

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Germline variants drive myelodysplastic syndrome in young adults

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Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

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Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia

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Activating JAK-mutations confer resistance to FLT3 kinase inhibitors in FLT3-ITD positive AML in vitro and in vivo

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Inactivating CUX1 mutations promote tumorigenesis

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Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation

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The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression

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Use of Gene-Expression Profiling to Identify Prognostic Subclasses in Adult Acute Myeloid Leukemia

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Molecular landscape and prognostic impact of FLT3-ITD insertion site in acute myeloid leukemia: RATIFY study results

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TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition

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Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN) - on behalf of the Ger...

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Genomic Aberrations and Survival in Chronic Lymphocytic Leukemia

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Publisher Correction: Significant association of cutaneous adverse events with hydroxyurea: results from a prospective non-interventional study in BCR-ABL1-negative myeloproliferative neoplasms (MPN)...

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