Serine is a natural ligand and allosteric activator of pyruvate kinase M2
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The M2 isoform of pyruvate kinase (PKM2) is a key glycolytic enzyme that is overexpressed in cancer cells; here, serine is shown to bind to and directly activate PKM2, and the resulting reduction in enzyme activity under serine-deprivation conditions is shown to lead to the diversion of glucose-derived carbon to promote serine biosynthesis required...
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Full title
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3894725
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3894725
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11540
