Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins
Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins
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Author / Creator
Zanier, Katia , Charbonnier, Sebastian , Sidi, Abdellahi Ould M'hamed Ould , McEwen, Alastair G. , Ferrario, Maria Giovanna , Poussin-Courmontagne, Pierre , Cura, Vincent , Brimer, Nicole , Babah, Khaled Ould , Ansari, Tina , Muller, Isabelle , Stote, Roland H. , Cavarelli, Jean , Pol, Scott Vande and Travé, Gilles
Publisher
United States: American Association for the Advancement of Science
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English
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United States: American Association for the Advancement of Science
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Contents
E6 viral oncoproteins are key players in epithelial tumors induced by papillomaviruses in vertebrates, including cervical cancer in humans. E6 proteins target many host proteins by specifically interacting with acidic LxxLL motifs. We solved the crystal structures of bovine (BPV1) and human (HPV16) papillomavirus E6 proteins bound to LxxLL peptides...
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Full title
Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3899395
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3899395
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1229934
