27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Hypercholesterolemia is a risk factor for estrogen receptor (ER)-positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here, we show that 27-hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and liver X receptor (LXR) ligand, increases ER-dependent growth and LXR-dependent metas...
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Full title
27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3899689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3899689
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1241908
