Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalani...
Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nuclear magnetic resonance, resistance by alpha-phen...
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Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3902384
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3902384
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep03875